journal-article · 2004 · en
Epigenetic Programming by Maternal Behavior
Weaver ICG, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ
Nature Neuroscience 7(8):847-854
Evidencia · Seminal
Síntesis
Landmark animal study: variation in maternal licking-grooming in rats alters DNA methylation of the glucocorticoid receptor (NR3C1) hippocampal promoter in offspring, with lifelong HPA-axis consequences. Founding paper of behavioral epigenetics.
Etapas
0-1, transversal
Dominios
parenting-styles, neuroscience, epigenetics
Tags
maternal-licking-grooming · NR3C1 · glucocorticoid-receptor · methylation · Meaney · Szyf · rat-model
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata