meta-analysis · 2009 · en
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-Analysis
Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR
JAMA 301(23):2462-2471
Evidencia · Seminal
Síntesis
Meta-analysis of 14 studies (n=14,250) found no evidence that 5-HTTLPR moderates depression risk from stressful events. Triggered the candidate-gene replication crisis and shifted psychiatric genetics toward GWAS.
Etapas
transversal
Dominios
mental-health, behavioral-genetics
Tags
5-HTTLPR · meta-analysis · GxE · replication-failure · candidate-gene-crisis · Risch
Afirmaciones que citan esta fuente (1)
clm-candidate-gene-gxe-replication-crisis
Early candidate-gene gene-environment interaction findings (5-HTTLPR with stress for depression; MAOA with maltreatment for antisocial behavior) failed large meta-analytic replication; modern psychiatric genetics has shifted to well-powered GWAS and polygenic scores.