review · 2015 · en
The Effects of Early Life Stress on the Epigenome: From the Womb to Adulthood and Even Before
Provençal N, Binder EB
Experimental Neurology 268:10-20
Evidencia · Alta
Síntesis
Review synthesizing animal and human evidence on epigenome-wide effects of early-life stress and the interplay with genotype (FKBP5, NR3C1) and developmental windows of plasticity.
Etapas
0-1, 1-3, transversal
Dominios
trauma, epigenetics, mental-health
Tags
early-life-stress · methylome · FKBP5 · NR3C1 · review · Provencal
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata