cohort · 2008 · en
Prenatal Exposure to Maternal Depression, Neonatal Methylation of Human Glucocorticoid Receptor Gene (NR3C1) and Infant Cortisol Stress Responses
Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM
Epigenetics 3(2):97-106
Evidencia · AltaOpen Access
Síntesis
First human evidence linking prenatal maternal mood (3rd trimester depression) to NR3C1 methylation in neonatal cord blood and altered infant cortisol response at 3 months.
Etapas
0-1
Dominios
perinatal, neuroscience, epigenetics, mental-health
Tags
prenatal-depression · NR3C1 · cord-blood · methylation · infant-cortisol · fetal-programming
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata