review · 2004 · en
Late Neurocognitive Sequelae in Survivors of Brain Tumours in Childhood
Mulhern R K, Merchant T E, Gajjar A, Reddick W E, Kun L E
The Lancet Oncology
Evidencia · Seminal
Síntesis
Classic synthesis showing that cranial irradiation in children, especially under age 7, drives progressive IQ decline (3-5 points/year) via white-matter injury; volume, dose and developmental stage are key moderators.
Etapas
3-6, 6-12, 12-18
Dominios
oncology, cognitive, neurology
Tags
brain-tumor · cranial-radiation · white-matter · IQ-decline · posterior-fossa
Afirmaciones que citan esta fuente (1)
clm-cranial-radiation-cognition
Cranial radiotherapy in childhood, especially before age 7, produces progressive declines in IQ, attention, processing speed and executive function, mediated by white-matter injury and partially mitigated by reduced-dose and proton protocols.