journal-article · 2009 · en
Epigenetic Regulation of the Glucocorticoid Receptor in Human Brain Associates with Childhood Abuse
McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ
Nature Neuroscience 12(3):342-348
Evidencia · SeminalOpen Access
Síntesis
First human translation of Meaney rat work: post-mortem hippocampi of suicide victims with childhood-abuse histories show increased NR3C1 promoter methylation and reduced GR expression vs controls.
Etapas
transversal
Dominios
trauma, neuroscience, epigenetics, mental-health
Tags
NR3C1 · methylation · childhood-abuse · suicide · post-mortem-brain · Quebec-Suicide
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata