meta-analysis · 2018 · en
Gene Discovery and Polygenic Prediction from a Genome-Wide Association Study of Educational Attainment in 1.1 Million Individuals
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, et al.
Nature Genetics 50(8):1112-1121
Evidencia · SeminalOpen Access
Síntesis
EA3 GWAS of educational attainment (n=1.1M) identifying 1,271 SNPs and yielding polygenic scores explaining ~11-13% variance, useful in developmental research for testing rGE and child-driven parenting effects.
Etapas
6-12, 12-18, transversal
Dominios
cognitive-development, behavioral-genetics, education
Tags
GWAS · educational-attainment · polygenic-score · EA3 · cognitive-genetics
Afirmaciones que citan esta fuente (1)
clm-gwas-polygenic-architecture
Well-powered GWAS show that schizophrenia, autism and educational attainment are polygenic, with hundreds to thousands of small-effect common variants converging on synaptic and neurodevelopmental biology; polygenic scores are useful research tools but not clinically diagnostic i