cohort · 2013 · en
Neurocognitive Outcomes Decades After Treatment for Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study
Krull K R, Brinkman T M, Li C, Armstrong G T, Ness K K, Srivastava D K, Gurney J G, Kimberg C, Krasin M J, Pui C-H, Robison L L, Hudson M M
Journal of Clinical Oncology
Síntesis
Etapas
6-12, 12-18, transversal
Dominios
oncology, cognitive, survivorship
Tags
ALL · neurocognitive · late-effects · CCSS · leukemia-survivors · attention · working-memory
Afirmaciones que citan esta fuente (2)
clm-ccss-late-effects
Survivors of childhood cancer carry a high cumulative burden of severe chronic health conditions (>50% by midlife), neurocognitive impairment, and excess late mortality, requiring lifelong risk-based survivorship surveillance.
clm-cranial-radiation-cognition
Cranial radiotherapy in childhood, especially before age 7, produces progressive declines in IQ, attention, processing speed and executive function, mediated by white-matter injury and partially mitigated by reduced-dose and proton protocols.