journal-article · 2013 · en
Allele-Specific FKBP5 DNA Demethylation Mediates Gene-Childhood Trauma Interactions
Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, et al.
Nature Neuroscience 16(1):33-41
Evidencia · Seminal
Síntesis
Demonstrates that the FKBP5 risk allele interacts with childhood trauma to produce allele-specific demethylation in intron 7, providing a mechanism for genotype-by-trauma effects on adult psychopathology.
Etapas
transversal
Dominios
trauma, epigenetics, mental-health, behavioral-genetics
Tags
FKBP5 · methylation · childhood-trauma · GxE · glucocorticoid-signaling
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata