meta-analysis · 2019 · en
Identification of Common Genetic Risk Variants for Autism Spectrum Disorder
Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, et al.
Nature Genetics 51(3):431-444
Evidencia · SeminalOpen Access
Síntesis
First well-powered autism GWAS (n=18,381 cases / 27,969 controls) identifying 5 genome-wide significant loci and demonstrating substantial polygenic overlap with educational attainment and other psychiatric traits.
Etapas
0-1, 1-3, 3-6, 6-12
Dominios
autism, behavioral-genetics, mental-health
Tags
GWAS · autism · iPSYCH · polygenic-score · common-variants
Afirmaciones que citan esta fuente (1)
clm-gwas-polygenic-architecture
Well-powered GWAS show that schizophrenia, autism and educational attainment are polygenic, with hundreds to thousands of small-effect common variants converging on synaptic and neurodevelopmental biology; polygenic scores are useful research tools but not clinically diagnostic i