review · 2014 · en
20 YEARS OF LEPTIN: Human Disorders of Leptin Action
Farooqi I S, O'Rahilly S
Journal of Endocrinology
Evidencia · SeminalOpen Access
Síntesis
Authoritative review of human leptin deficiency and leptin-melanocortin pathway disorders (LEP, LEPR, POMC, MC4R) as causes of severe early-onset obesity and hyperphagia; basis for setmelanotide therapy.
Etapas
0-1, 1-3, 3-6, 6-12
Dominios
endocrine, obesity, genetics
Tags
leptin · melanocortin · monogenic-obesity · MC4R · Farooqi
Afirmaciones que citan esta fuente (1)
clm-obesity-endocrine-model
Childhood obesity is driven in significant part by hormonal mechanisms (hyperinsulinemia, leptin-melanocortin pathway dysfunction, hypothalamic dysregulation) rather than purely behavioral failure; treatment must move beyond willpower framing toward IHBLT, pharmacotherapy and, wh