meta-analysis · 2011 · en
A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry
Duncan LE, Keller MC
American Journal of Psychiatry 168(10):1041-1049
Evidencia · AltaOpen Access
Síntesis
Systematic review showing 96% of novel candidate-gene GxE findings reported significant interactions but only 27% of replication attempts succeeded; strong evidence of publication bias and false positives.
Etapas
transversal
Dominios
mental-health, behavioral-genetics
Tags
candidate-gene · GxE · replication · publication-bias · psychiatric-genetics
Afirmaciones que citan esta fuente (1)
clm-candidate-gene-gxe-replication-crisis
Early candidate-gene gene-environment interaction findings (5-HTTLPR with stress for depression; MAOA with maltreatment for antisocial behavior) failed large meta-analytic replication; modern psychiatric genetics has shifted to well-powered GWAS and polygenic scores.