review · 2008 · en
Epigenetic Mechanisms and the Transgenerational Effects of Maternal Care
Champagne FA
Frontiers in Neuroendocrinology 29(3):386-397
Evidencia · SeminalOpen Access
Síntesis
Authoritative review by Champagne synthesizing animal evidence that variation in maternal care induces DNA methylation changes that program offspring stress reactivity, sexual behavior and maternal behavior across generations.
Etapas
0-1, 1-3, transversal
Dominios
parenting-styles, neuroscience, epigenetics
Tags
maternal-care · epigenetics · transgenerational · NR3C1 · estrogen-receptor · Champagne
Afirmaciones que citan esta fuente (1)
clm-epigenetic-programming-care-and-fetal
Maternal care in rodents programs offspring HPA-axis reactivity through DNA methylation of the glucocorticoid receptor (NR3C1); analogous, smaller-magnitude associations exist in humans between prenatal mood/stress and NR3C1/FKBP5 methylation in placenta or cord blood and neonata