longitudinal · 2003 · en
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R
Science 301(5631):386-389
Evidencia · Seminal
Síntesis
Foundational GxE paper: short 5-HTTLPR allele moderates the depressogenic effect of stressful life events. Catalyzed a decade of candidate-gene GxE research before failing major meta-analyses.
Etapas
12-18, transversal
Dominios
mental-health, trauma, behavioral-genetics
Tags
5-HTTLPR · serotonin-transporter · depression · stressful-life-events · GxE · Dunedin
Afirmaciones que citan esta fuente (1)
clm-candidate-gene-gxe-replication-crisis
Early candidate-gene gene-environment interaction findings (5-HTTLPR with stress for depression; MAOA with maltreatment for antisocial behavior) failed large meta-analytic replication; modern psychiatric genetics has shifted to well-powered GWAS and polygenic scores.