longitudinal · 2002 · en
Role of Genotype in the Cycle of Violence in Maltreated Children
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R
Science 297(5582):851-854
Evidencia · Seminal
Síntesis
Landmark Dunedin study: low-activity MAOA allele moderates the effect of childhood maltreatment on adult antisocial behavior. First widely replicated candidate-gene GxE finding (though later subject to meta-analytic debate).
Etapas
6-12, 12-18, transversal
Dominios
mental-health, trauma, behavioral-genetics
Tags
MAOA · gene-environment-interaction · maltreatment · Dunedin · antisocial-behavior · GxE
Afirmaciones que citan esta fuente (1)
clm-candidate-gene-gxe-replication-crisis
Early candidate-gene gene-environment interaction findings (5-HTTLPR with stress for depression; MAOA with maltreatment for antisocial behavior) failed large meta-analytic replication; modern psychiatric genetics has shifted to well-powered GWAS and polygenic scores.