review · 2016 · en
Epigenome-Wide Association Studies and the Interpretation of Disease -Omics
Birney E, Smith GD, Greally JM
PLOS Genetics 12(6):e1006105
Evidencia · SeminalOpen Access
Síntesis
Influential methodological critique by Ewan Birney: most EWAS findings cannot distinguish cause from consequence, are vulnerable to reverse causation and cell-type confounding, and require Mendelian randomization or longitudinal designs.
Etapas
transversal
Dominios
epigenetics, behavioral-genetics
Tags
EWAS · critique · reverse-causation · confounding · Birney · methylation-interpretation
Afirmaciones que citan esta fuente (1)
clm-epigenetics-hype-critique
Popular claims of broad transgenerational epigenetic inheritance of trauma in humans outrun the evidence; germline reprogramming is a substantial barrier in mammals, and most epigenome-wide associations cannot distinguish cause from consequence without longitudinal or Mendelian-r